Most played cards in Smallpox:

4 Decks
Dark Confidant
16 copies - 4 average
Smallpox
13 copies - 3.25 average
Chrome Mox
12 copies - 3 average
Gerrard's Verdict
12 copies - 3 average
Kataki, War's Wage
12 copies - 3 average
Vindicate
12 copies - 3 average
Flagstones of Trokair
12 copies - 3 average
Polluted Delta
10 copies - 2.5 average
Duress
10 copies - 2.5 average
Trinket Mage
9 copies - 2.25 average
Jötun Grunt
9 copies - 2.25 average
Godless Shrine
9 copies - 2.25 average
Descendant of Kiyomaro
9 copies - 2.25 average
6 copies - 1.5 average
Tormod's Crypt
6 copies - 1.5 average
Ghastly Demise
6 copies - 1.5 average
Rancid Earth
6 copies - 1.5 average
Serra Avenger
6 copies - 1.5 average
Engineered Explosives
5 copies - 1.25 average
Extirpate
5 copies - 1.25 average