Most played cards in Rebels:

61 Decks
Swords to Plowshares
244 copies - 4 average
Ramosian Sergeant
235 copies - 3.85 average
Adarkar Wastes
185 copies - 3.03 average
Mother of Runes
175 copies - 2.87 average
Lin Sivvi, Defiant Hero
166 copies - 2.72 average
Mana Leak
155 copies - 2.54 average
Counterspell
150 copies - 2.46 average
Flooded Strand
144 copies - 2.36 average
Disenchant
128 copies - 2.1 average
Defiant Falcon
127 copies - 2.08 average
Whipcorder
109 copies - 1.79 average
Standstill
104 copies - 1.7 average
Meddling Mage
104 copies - 1.7 average
Coastal Tower
103 copies - 1.69 average
Tormod's Crypt
80 copies - 1.31 average
Mishra's Factory
78 copies - 1.28 average
Shared Triumph
78 copies - 1.28 average
Hydroblast
59 copies - 0.97 average
Thermal Glider
54 copies - 0.89 average
Defiant Vanguard
51 copies - 0.84 average